It is also notable that although the two pathogenic CAH‐X chimeras (CH‐1 and CH‐2) cause EDS in an autosomal dominant manner regardless of the CAH status, the EDS manifestations are usually milder in CAH carriers compared to CAH patients, suggesting potential hormonal effects on the EDS phenotype (Merke et al., 2013; Morissette et al., 2015). The gene discussed is C4B; the disease is congenital adrenal hyperplasia.