In a periodontal disease scenario, we propose the following possible virulence activities related to Pg‐linked MUC5AC stimulation: (a) Oral Pg secretes Kgp and Rgp, which in turn travels down to pulmonary tissues (such as the tracheal and bronchial tissues) and, consequently, induces MUC5AC among pulmonary epithelial cells; and (b) oral Pg (bacterial cell itself) weakly attaches along pulmonary tissues and, concurrently, secretes Pg gingipains, which may result in higher levels of MUC5AC stimulation. The gene discussed is MUC5AC; the disease is periodontal disorder.