In particular, Pg gingipains are a type of protease enzyme that accounts for 85% of extracellular proteolytic activity at the site of infection [39] leading to multiple infection events, including adhesion, hemagglutination, hemolysis, heme acquisition, degradation of host proteins, in housekeeping for gingipain maturation, dysregulation of host response, and tissue matrix destruction [40]. This evidence concerns the gene JUP and infection.