More patients with DCISM had menopause (P = 0.026) and a palpable mass (P = 0.030) with a larger size (P = 0.018) while more DCIS patients had estrogen receptor (ER) positivity (P = 0.033) and PR positivity (P = 0.017). Here, ESR1 is linked to ductal breast carcinoma in situ.