NOX4 and liver dysplastic nodule: Based on these findings, here we attempt to address (a) The therapeutic effects of SAL in db/db diabetic mice; (b) the role of Sal B on NOX4 activity, NOX4‐derived mitochondrial ROS production and apoptosis of podocytes under high glucose; and (c) whether AMPK is required for Sal B to attenuate NOX4‐induced podocyte injury in DN.