The role of miR‐125b in the signalling pathways that underlie cancer development and progression has been explored comprehensively, and it is known to act largely through its multiple molecular targets, which are involved in signalling cascades, such as the canonical Wnt, PI3K/Akt, STAT‐3, MAPK, NF‐κB and p53 pathways. The gene discussed is NFKB1; the disease is cancer.