For example, the enhanced expression of miR‐125b in hepatocellular carcinoma cells reduces doxorubicin/sorafenib resistance by negatively regulating both SMAD2 and SMAD4, as well as multidrug resistance genes, such as PGP, ABCC1 and ABCCG2. 147In addition, an overexpression of lncRNA MIR100HG‐derived miR‐125b has been observed in cetuximab‐resistant colorectal cancer cells, head and neck squamous cell cancer cells and colorectal cancer patients by repressing GATA6 and thus activating the Wnt/β‐catenin signalling pathway.148. This evidence concerns the gene SMAD4 and colorectal cancer.