However, when the 25 lipid species with the lowest p ‐values were represented using hierarchical clustering analyses, as shown in a heatmap (Figure 3B), a clear separation between groups was observed revealing a specific shared trend in patients with neurodegenerative diseases within the ALS‐FTLD‐TDP43 proteinopathy spectrum. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.