Globally, we have demonstrated minor changes in peroxisome‐related gene expression that is mostly involved in lipid metabolism with phenotypic changes affecting ether lipids and acylcarnitine, whereas fatty acid metabolism seems to be preserved in the human frontal cortex in the ALS‐FTLD‐TDP43 proteinopathy spectrum. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.