In CSF, we observed that of 16 reliable assays (Supporting Information Table S3; Supporting Information Fig. S2), 7 showed PD‐related changes with P < 0.05: VCAM‐1 (vascular cell adhesion molecule 1), ICAM‐1 (Intercellular Adhesion Molecule 1), IL‐8, SAA (Serum amyloid A), PIGF (Placental growth factor), IL‐15, and VEGF‐D (Vascular endothelial growth factor‐D) were increased in patients with PD (Fig. 3A–K). This evidence concerns the gene CXCL8 and Parkinson disease.