More importantly, sCD163 was also strongly correlated with regulators of angiogenesis, blood–brain barrier (BBB) extravasation, and/or monocyte brain infiltration or recruitment,41, 42, 43, 44, 45 which have been reported to be increased in PD,46, 47, 48 namely, ICAM‐1, VCAM‐1, and VEGF‐D in both serum and CSF, and IL‐8, IL‐15, and PIGF only in CSF. This evidence concerns the gene ICAM1 and Parkinson disease.