Therefore, NPS receptor the NPSR1with elevated agonistic response possibly may contribute towards hyper-stimulation and neurotransmission which ultimately may result in the pathophysiology of obesity in the Pakistani population, but still, further investigations with larger data sets are required to evaluate in the context of NPS-NPSR1 interaction. This evidence concerns the gene NPSR1 and obesity due to melanocortin 4 receptor deficiency.