This may because of environment-dependent expression of NPSR1 gene, as revealed earlier in malnourished individuals with TT genotype were found highly sensitive against depression and anxiety [11] and that may be the reason for the association of (rs324981) T allele with anxiety [34] impulsivity [35] sleep disorder [36] and panic disorder [37, 38]. The gene discussed is NPSR1; the disease is major depressive disorder.