In a study of 101 patients with sarcoidosis by Honda et al., patients with elevated KL-6 levels (mean 802.4 U/mL) had significantly more frequent parenchymal involvement (ground-glass opacities, nodules, interlobular septal thickening, traction bronchiectasis, architectural distortion, and bronchial wall thickening) on chest CT than those with normal KL-6 levels (mean 305.7 U/mL) [37]. This evidence concerns the gene MUC1 and sarcoidosis.