ADA and hematologic disorder: When subgroups were separated by diagnoses, 30 of 105 (28.6%) patients with hematologic malignancies had a VUS in a relevant gene associated with childhood onset (A2ML1, ADA, ATM, BLM, BRCA2, CREBBP, DDX41, DNAJC21, EFL1, EP300, ERCC6L2, FANCF, MAP2K2, PARN, PAX5, PTPN11, RPL5, RRAS, SH2D2A, SHOC2, SOS2, TERT, TNFRSF13B).