We selected highly significant eQTLs (FCGR3A (Fc fragment of IgG receptor IIIa):rs12087446 and DNALI1 (dynein axonemal light intermediate chain 1):rs12119598) based on FCGR3A and DNALI1’s role as network hubs to highlight the interaction between AD case status and eQTL while also demonstrating brain region-specific eQTL variation. This evidence concerns the gene FCGR3A and Alzheimer disease.