ZEB1/2 proteins are hallmarks of epithelial-mesenchymal transition (EMT) and cofactors chemoresistance in PC (Orellana-Serradell et al. 2019) while BMI1 promotes cell proliferation, EMT and is critical for the development of castration-resistance in PC (Zhu et al. 2020). This evidence concerns the gene ZEB1 and pachyonychia congenita.