CD4 and AIDS: However, in spite of the updated recommendations on a higher T-CD4+ threshold over the years, the mean incidences of AIDS cases (per 100.000 inhabitants) has not been reduced as expected: 20.4 (2004-2007); 21.6 (2008-2012); 20.2(2013-2016); 18.1 (2017-2018: preliminary data), respectively20-.23