The expression of Wnt3a in the present study, in 43.4% of the evaluated samples, wasnoticeably lower than that described by Qi et al., where 172 (88.2%) of 203 CRCsamples demonstrated positive expression of Wnt3a, and the cases with strongexpression were related to less differentiated tumors, advanced clinical stage,presence of metastasis and with tumor recurrence.22 Here, WNT3A is linked to neoplasm.