Univariate Cox proportional hazards regression model analysis indicated that KIF2A high expression (P=0.002), WBC >10×109/L (P=0.044), monosomal karyotype (P<0.001), NPM1 mutation (P=0.046), and high risk stratification were associated with worse OS and multivariate Cox proportional hazards regression model analysis showed that WBC >10×109/L (P=0.002) and high risk stratification were independent factors predicting worse OS in AML patients (Table 4). The gene discussed is NPM1; the disease is acute myeloid leukemia.