Considering the importance of BDNF and astrocytes for depression and neural plasticity, we also aimed at studying BDNF and GFAP, at two time-points (day 1, D1; 30 days later, D30) after a single KET injection, in order to have some insight on the rapid and, especially, the long-lasting effects of KET. The gene discussed is BDNF; the disease is depressive disorder.