Western blot analyses on tumor lysates demonstrated that the combination treatment induced a clear reduction in HSP90α and of total HSP90 levels that was accompanied by a prominent increase of PARP1 and caspase 3 cleavage and of γH2AX expression, compared with the other groups, confirming in vivo what observed in vitro (Fig. 7E). The gene discussed is PARP1; the disease is neoplasm.