AKT1 and cardiac hypertrophy: On the other hand, Ang-(1-7), the product of ACE2 activity, stimulated ANP secretion through the Mas receptor/phosphatidylinositol 3-kinase/protein kinase B (Mas/PI3K/Akt) pathway, thus reducing cardiac hypertrophy and fibrosis and potentially avoiding COVID-19 pulmonary damage (8).