Concordant with the role of iRhom2 in regulating inflammatory processes and adipose tissue homeostasis during obesity (77), activation of ADAM17 has been shown to promote metabolic inflammation, presumably through the release of inflammatory cytokines such as TNF and regulation of pathways involved in adipose tissue infiltration by immune cells (78, 79). The gene discussed is RHBDF2; the disease is obesity due to melanocortin 4 receptor deficiency.