In this study, we investigated the expression levels of OPN and correlated proteins, dynamin2 (DNM2), low density lipoprotein (LDLR), 2-oxoglutarate dehydrogenase-like (OGDHL), and fibronectin-1 (FN1), in the hearts of SCD victims who had both DM and HFpEF. The gene discussed is LDLR; the disease is diabetes mellitus.