LGALS3 and hydrops fetalis: In two large cohorts of chronic HF and acute decompensated HF patients, the prognostic value of Gal-3 serial measurements in HF patients at baseline vs. 3-months follow-up (CORONA study) and baseline vs. 6-month follow-up (COACH study) revealed that an increase of Gal-3 at follow-up was associated with an increased rate of re-hospitalization and mortality (hazard ratio in CORONA, 1.60; 95% CI, 1.13–2.25; p = 0.007; hazard ratio in COACH, 2.38; 95% CI, 1.02–5.55; p = 0.046) (104).