Natriuretic Peptides (NP), i.e., brain-type natriuretic peptide (BNP) and N-terminal prohormone of BNP, and cardiac troponin measurements have been included in the guidelines for HF diagnosis and treatment of the European Society of Cardiology (ESC) (16) and the American Heart Association (AHA) (17). This evidence concerns the gene NPPB and hydrops fetalis.