ERBB2 and cancer: However, anthracycline-induced cardiotoxicity is associated with a poor prognosis in cancer survivors, and the frequency of onset depends on risk factors including cumulative dose of anthracycline, elderly or pediatric population, concomitant or previous radiation therapy, pre-existing cardiovascular diseases, and concomitant use of human epidermal growth factor receptor 2 (HER2) inhibitors (1).