The value of NRI and IDI for detecting CTRCD reached statistical significance when baseline RDW value was added to the model including cumulative dose of anthracycline, EF, albumin and hypertension; 0.9252 (95%CI 0.4103–1.4402, P < 0.001) for NRI and 0.1125 (95%CI 0.0078–0.2171, P = 0.035) for IDI. This evidence concerns the gene ALB and Hypertension.