KLF5 and infection: As showed in Figure 4F, luciferase activity of the WT-Klf5 reporter was significantly enhanced upon pLV-FTO infection, whereas it didn't affect the luciferase activity of the Mut-Klf5 reporter, suggesting that Klf5 is functionally an important target of FTO via its m6A demethylase activity in the Klf5 mRNA transcript.