Parallelly, Klf5 expression was also significantly higher in AD and AA tissues than control (AD: 51.4 ± 3.5%, AA: 38.6 ± 4.9% vs. Control: 6.7 ± 1.1%, P < 0.01, and P < 0.05, respectively) (Figure 1D). This evidence concerns the gene KLF5 and Alzheimer disease.