To explore actively participating IRGs in the incidence and progression of HNSCC, we ascertained 64 IRGs that are differentially expressed and related to survival as hub IRGs (Table 1), including six chemokine-related genes, six interleukin (IL)-related genes, 12 growth factor-related genes, five protease-related genes, seven T- and B-cell surface molecule-related genes, six kinase-related genes, and 22 genes encoding other proteins. The gene discussed is TBXT; the disease is head and neck squamous cell carcinoma.