On molecular level, AD shows the accumulation of two distinct proteins; extracellular plaques of amyloid-β and intracellular formation of neurofibrillary tangles of Tau; a microtubule associated protein assisting in microtubule stability and regulating axonal transport (Drubin and Kirschner, 1986; Goedert et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.