Out of 10 mammalian sHSPs, four family members are expressed in neurons and play a role in neurodegenerative diseases: HSPB1, HSPB5, HSPB8 and to a lower extend, HSPB6 (Quraishe et al., 2008; Webster et al., 2019). Here, CRYAB is linked to neurodegenerative disease.