SETD2 and cancer: Results of a rodent study with lactating dams (Sprague-Dawley rats) shows that dietary genistein (250 ppm/diet) to achieve physiologically relevant serum concentrations (~700 pmol/L) induces in offspring expression of factors involved in cancer prevention including MMP3; rho-associated coiled-coil containing protein kinase 2 (ROCK2); neurosecretory protein VGF 8a (VGF), serine (or cysteine) proteinase inhibitor clade A (SERPINA1); ubiquitin carboxyl-terminal hydrolase L5 (UCH1); SET domain containing 2 (SETD2); and protein tyrosine phosphatase receptor type K (PTPRK) (107).