PLAUR and focal segmental glomerulosclerosis: A seemingly major breakthrough in FSGS pathogenesis ignited the renal community in 2011, when Wei and colleagues identified the soluble urokinase plasminogen activator receptor (suPAR) as a possible circulating permeability factor; suPAR is the cleaved form of a membrane-bound glycoprotein (uPAR) that interacts with podocyte αvβ3 integrins, membrane proteins that connect actin filaments with the extracellular matrix.