Accordingly, IFNpos SLE patients, in addition to the activation of senescent T-cells, presented high serum levels of several inflammatory cytokines and chemokines, including IL-6, IFNγ, ICAM-1, CXCL10, CCL2, and CCL3, than their IFNneg counterparts. This evidence concerns the gene CCL3 and systemic lupus erythematosus.