The analysis of blood cellular subsets revealed higher levels of activated and senescent CD4+ lymphocytes (no-Treg CD25+ and CD28null, respectively) in SLE patients compared to controls, whereas resting T-cells were decreased (Figure 1B) and an increase was observed for FOXP3+ Treg cells [1.34 (0.80) vs. 0.91 (1.27); p = 0.010]. This evidence concerns the gene CD4 and systemic lupus erythematosus.