TNFSF11 and rheumatoid arthritis: Furthermore, in a phase II trial to assess the efficacy of denosumab, a RANKL inhibitor human antibody, on several bone parameters in patients with RA, they found that the association of denosumab with methotrexate and other therapies for controlling RA reduces bone erosions, increases BMD and decreases biomarkers of bone resorption, so it could be a potential treatment for erosive RA (58).