TNFSF4 and systemic sclerosis: Genotype–phenotype association analysis and meta-analysis confirmed TNFSF4 as an SSc susceptibility gene and rs2205960 as a putative causal variant with a preferential association with the ACA-positive SSc subtype (P = 0.0015, OR = 1.37, 95% CI = 1.12–1.66) (71).