ATM and systemic sclerosis: Nihtyanova et al. proposed seven groups of patients with SSc, combining autoantibody specificity and skin involvement (ATA + lcSSc, ATA + dcSSc, ACA + lcSSc, ARA+, other antibodies + lcSSc, other antibodies + dcSSc) (111) while Sobanski et al. (112) characterized six clusters based on antibody profiles (cutaneous subsets, organ damage, and prognosis together), thereby achieving a more precise risk stratification of patients.