AIF1 and systemic sclerosis: Moreover, genetic association between AIF1 polymorphism and the ACA-positive subset of SSc was confirmed (P = 0.006/0.002 in Caucasians/combined group, OR = 1.53/1.56 in Caucasians/combined group, 95% CI = 1.11–2.11/1.18–2.07 in Caucasians/combined group) (66).