Digenic inheritance has also already been reported to have a prognostic role in other kidney diseases, such as congenital nephrotic syndrome (mutations in NPHS1 and NPHS2) (31), autosomal dominant polycystic kidney disease (mutations in PKD1 and PKD2) (32) and Bartter's syndrome (33). The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.