Also, it has been described that WNT/β-catenin signaling induces IL-1β expression by alveolar epithelial cells in a murine model of pulmonary fibrosis and an up-regulation of IL-1β in bronchoalveolar lavage fluid (BALF) in bleomycin-induced lung fibrosis in vivo (35). This evidence concerns the gene IL1B and pulmonary fibrosis.