NDUFV1 and Parkinson disease: The link between mitochondrial dysfunction and PD dates back to 1982 when seven adolescents developed parkinsonism shortly after injection of synthetic heroin containing byproduct 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a specific mitochondrial respiratory chain complex I inhibitor (Nonnekes et al., 2018).