While viral infection with Hepatitis C (HCV) in the cells does not alter expression of LRRFIP1 itself, the induction of IFN by LRRFIP1 is also exacerbated by HCV infection, and the upregulation of IFN acts to inhibit the replication of the virus (Liu et al., 2015). The gene discussed is IFNA1; the disease is viral infectious disease.