An opposing effect of Flii upon invasion is evident in human bronchial epithelial cells, where Flii expression is reduced in lung carcinoma cells lines H1299 and A529 compared to normal cells and reducing Flii by siRNA knockdown stimulates invasion, whereas Flii overexpression shows inhibition of this process (Wang et al., 2017). The gene discussed is FLII; the disease is lung carcinoma.