TNF and COVID-19: Thus, The COVID-19 consequent cytokine-storm constitutes on a large expression of IL-6 and TNF-α, but recent investigations also showed that high levels of IFN-y, interleukin (IL)- 1β, 2, 4, 6, 8, 10, 17, induced protein 10 (IP10), monocyte chemoattractant protein-1 (MCP-1), are also significantly elevated in patients with severe COVID-19 (Hu et al., 2020).