TMPRSS2 and severe acute respiratory syndrome: Like it is observed in other SARS-CoV infections, the S protein of SARS-CoV-2 is able to bind the ACE-2 which allows the cell entering catalyzed by transmembrane protease serine-2 (TMPRSS2) protease mostly in type II alveolar cells in the pulmonary parenchyma but also other target cells that express ACE-2 (Spike, 2010).