Notably, YAP, a mammalian homolog of Yorkie, target genes were upregulated in colon cancer C26 cells, and NRS inhibitor TirB decreased the levels of YAP target genes and suppressed cell proliferation in C26 cells, indicating that NRS might regulate the development of colon cancer by Hippo signaling pathway (Yeom et al., 2020). Here, NARS1 is linked to colonic neoplasm.