Recent studies discovered that four single nucleotide polymorphisms (SNPs) in ARS genes, including rs34087264 in alanyl-tRNA synthetase (AlaRS), rs801186 in histidyl-tRNA Synthetase (HARS), rs193466 in arginyl-tRNA synthetase (RARS) and rs2273802 in tryptophanyl-tRNA synthetase (WARS), were significantly associated with an increased risk of breast cancer in Chinese population (He et al., 2015). Here, HARS1 is linked to breast cancer.