In Sirt3 heart-specific knockout (SIRT3–/–) mice, Sirt3 deficiency weakened resistance to oxidative stress, disrupted mitochondrial homeostasis, and finally resulted in obvious aging features in the myocardium, which suggested that Sirt3 might regulate age-related heart diseases by maintaining the normal biological functions of the mitochondria (Li et al., 2018). The gene discussed is SIRT3; the disease is heart disorder.