Vascular endothelial growth factors (VEGFs), including VEGFA, VEGFB, VEGFC, VEGFD, VEGFE, and placental growth factor, are very important mediators of lymphangiogenesis and angiogenesis during tumor development (Pang et al., 2017; Mesquita et al., 2018; Yang et al., 2018). This evidence concerns the gene VEGFA and neoplasm.