NOTCH1 and neoplasm: Jang et al. (2017) found that VEGFA stimulated ovarian cancer stem-like cells through Src-DNMT3A-driven miR-128-2 methylation and Bmi1 upregulation. The research of Cybulski et al. (2012) indicated that elevated expression of cyclin I and KDR was likely to provide a proliferative advantage to human epithelial ovarian cancer cells. Meanwhile, KDR silencing by siRNA suppressed epithelial ovarian cancer invasion (Wang et al., 2009). Furthermore, Chen et al. (2019) found that circ-ASH2L promoted tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma.