SNX27 and neurodegenerative disease: Given that synaptic dysfunction and endo-lysosomal dysregulation represent the pathological features in neurodegenerative diseases (Acquarone et al., 2019; Chakroborty et al., 2019; Van Acker et al., 2019), such as Alzheimer’s disease (AD) and Down’s syndrome (DS), the role of SNX27 in these diseases has attracted extensive attention.