Given that synaptic dysfunction and endo-lysosomal dysregulation represent the pathological features in neurodegenerative diseases (Acquarone et al., 2019; Chakroborty et al., 2019; Van Acker et al., 2019), such as Alzheimer’s disease (AD) and Down’s syndrome (DS), the role of SNX27 in these diseases has attracted extensive attention. Here, SNX27 is linked to Alzheimer disease.