CDHR1 and Rod-cone dystrophy: While the mechanism as to how loss of CDHR1 function affects pathogenesis of cone-rod dystrophies is unknown, several studies have reinforced its importance to photoreceptor cell biology by characterizing its protein localization (Rattner et al., 2001, 2004; Burgoyne et al., 2015) and necessity for photoreceptor disk renewal (Ostergaard et al., 2010).