As revealed by many recent findings and the present study, the dysregulation of PERK/eIF2α is not only a detrimental downstream reaction caused by Aβ accumulation but also an important initial cause of the pathogenesis of AD (Ohno, 2014, 2018; Rozpedek et al., 2015; Bell et al., 2016; Hughes and Mallucci, 2018). This evidence concerns the gene EIF2A and Alzheimer disease.