Sustained eIF2α phosphorylation and subsequent persistent repression of global protein synthesis, which result in memory impairments and neurodegeneration during chronic diseases such as AD, are observed in the brains of sporadic AD patients as well as in different AD transgenic mouse models (Chang et al., 2002; Ferrer, 2002; Kim et al., 2007; O’connor et al., 2008; Morel et al., 2009; Ohno, 2014). Here, EIF2A is linked to Alzheimer disease.