Interestingly, two teams recently reported that AMPK could dephosphorylate TFEB/TFE3, induce their nuclear localization independently of mTOR activity (Collodet et al., 2019; El-Houjeiri et al., 2019), and activate TFEB/TFE3 boost the expression of lysosomal and inflammatory genes in macrophages in response to infection (Hipolito et al., 2018; El-Houjeiri et al., 2019). This evidence concerns the gene TFE3 and infection.