In addition, AMPK activation could induce apoptosis of ovarian cancer cells and delay endometrial cancer progression by inhibiting the mTOR and/or AKT pathways (Erdemoglu et al., 2009; Xie et al., 2011; Yung et al., 2016), which suggesting AMPK appears to serve as a tumor suppressor and exhibits an anti-cancer effect on genital system cancers. This evidence concerns the gene PRKAA2 and cancer.