Interestingly, a previous study exogenously overexpressing Tm7sf2 in the non-liver HT1080 human fibroblast cancer cell line tended to similarly alter the position and expression of liver genes (de las Heras et al., 2017); however, the specific genes changing tended to be different from those altered in the Tm7sf2–/– livers. This evidence concerns the gene TM7SF2 and cancer.