These include Atp6v0d2 encoding ATPase H+ transporting lysosomal V0 subunit D2 that is involved in insulin receptor recycling, Ces1g encoding carboxylesterase 1G that is involved in insulin resistance, and Irs1 and Irs2 encoding the insulin receptor substrate 1 and insulin receptor substrate 2 proteins that regulate insulin signaling. The gene discussed is IRS2; the disease is Insulin resistance.