Apart from its clear enzymatic role in cholesterol biosynthesis (Bennati et al., 2008), Tm7sf2 has been shown to be important for liver regeneration (Bartoli et al., 2016), in skin papilloma formation (Bellezza et al., 2015), and affecting nuclear factor kappa B (NF-κB) activity and TNFα expression (Bellezza et al., 2013; Gatticchi et al., 2015). This evidence concerns the gene TM7SF2 and skin papilloma.