The downregulation of Ccl2 (Salcedo et al., 2000; Lavender et al., 2017), Fosl1 (Lewçn et al., 2007; Luo et al., 2009), and Rgs1 (Hu et al., 2019) has been described to increase apoptosis and to decrease angiogenesis and tumor invasion by affecting molecules associated with these processes (e.g., VEGF, MMP-2, MMP-9). The gene discussed is MMP9; the disease is neoplasm.