ITGAM and cancer: In addition, based on previous works that utilized plasma EVs as biomarkers for diagnosis, prognosis, and follow-up of cancer patients (Peinado et al., 2012; Costa-Silva et al., 2015; Hoshino et al., 2015, 2020; Melo et al., 2015), it is possible that EV biomolecules linked with PC-CD11b+ BM cell communication may enable early detection of this process through the study of circulating plasma EVs.