FIS1 up-regulation decreased cellular ATP levels in anoxic cardiomyocytes and impaired glucose-stimulated insulin secretion in INS-1E cells (Park et al., 2008; Wang et al., 2012); and it has been identified as a molecular marker for poor prognosis in patients with acute myeloid leukemia (Tian et al., 2014). Here, INS is linked to acute myeloid leukemia.