APOE and age-related macular degeneration: Genome-wide association study has identified a list of AMD-associated genetic variations, including Complement factor family members (Edwards et al., 2005; Haines et al., 2005; Klein et al., 2005), Apolipoprotein E (APOE) (Ngai et al., 2011), Fibroblast growth factor 2 (FGF2) (Brion et al., 2011), DNA excision repair protein (ERCC6) (Baas et al., 2010) and Age-related maculopathy susceptibility protein 2 (ARMS2) (Micklisch et al., 2017).