SIRT1 and cancer: Since SIRT1 overexpression is associated with poor survival and prognostic outcomes including higher lymph node metastases in cancer patients (Wu et al., 2012), post-translational modifications of SIRT1 such as deacetylation, phosphorylation, sumoylation determine hormonal dependence and -independence of multiple cancers through understanding the interactive association between SIRT1 and steroid hormone receptors.