Promotes cell cycle arrest via hyperacetylation of tubulin, p53, Foxo3a, and KU70; reduced xenograft tumor growth in a mouse Burkitt lymphoma model; reduced neuroblastoma formation in N-Myc transgenic mice; and Repressed aromatase transcription via ERα deacetylation in breast cancerDecreased proinflammatory cytokines expression and macrophage response upon microbial stimulation (TLR) in vivo. The gene discussed is FOXO3; the disease is Burkitt lymphoma.