ESR1 and breast carcinoma: Resveratrol inhibited breast cancer cell growth and upregulated SIRT1 mRNA and protein expression (Lin et al., 2010) while SIRT1 pharmacological inhibitor, sirtinol and splitomicin along with anti-SIRT1 siRNA demonstrated repressed SIRT1 activity, resulting in inhibited ERα-mediated cancer gene transcription in an estrogen-independent manner.