SIRT1 and Familial prostate cancer: Apart from this, researchers also reported AR-sensitive prostate cancer progression via (a) transcriptional association between NF-κB and SIRT1 (Jaganathan et al., 2014), (b) SIRT1 dependent transcriptional upregulation of VEGF-C and downregulation of the IGF-1R pathway (Li et al., 2005), and (c) via endogenous SIRT1 mediated induction of autophagy in cultured cells (Powell et al., 2011).