In vivo and in vitro studies have shown that knocking down the expression of P2 × 7 receptor significantly inhibits the ATP or BzATP-driven expression changes of EMT-related genes Snail, E-cadherin, and MMP-3, and inhibits the migration and metastasis of prostate cancer cells (Qiu et al., 2014). Here, MMP3 is linked to prostate cancer.