Heterozygous (het) mutations of SYNGAP1, important for synaptogenesis and regulation of excitatory synapses (Rumbaugh et al., 2006; Walkup et al., 2015), are associated with neurodevelopmental disorders, including epilepsy, ASD, and ID (Gamache et al., 2020). This evidence concerns the gene SYNGAP1 and neurodevelopmental disorder.