TRPC1 and Parkinson disease: Other pathways that were affected in PD due to reduced TRPC1 expression include attenuation of autophagy as well as impairment of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and Tropomyosin receptor kinase A (TrkA) signaling (Yu et al., 2013; Sukumaran et al., 2018).